Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability

Suhas S. Kharat & Shyam K. Sharan et al. · 2020-08-18

Loss of DNA demethylase TET2 protects stalled replication forks from degradation and confers chemoresistance.

Links

Journal

Science Signaling

Institutions

National Cancer Institute Httpsrororg040gcmg81 Leidos Biomedical Research Inc United States National Institutes Of Health

Authors

Suhas S. Kharat, Xia Ding, Divya Swaminathan, Sandra Burkett, Hanna Marks, Yafeng He, Stephen D. Fox, Eugen C. Buehler, Shyam K. Sharan

Funding

Functional Evaluation of BRCA2 Variants on Tumorigenesis Identification of genetic interactors of BRCA2 NCI, NIH Intramural Program Funding Department of Defense, Breast Cancer Research Program Grant W81XWH-13-1-0362

Intramural NIH HHS

ZIA BC010387

Intramural NIH HHS

ZIA BC011311