A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer

Sara Bobisse & George Coukos et al. · 2023-09-21

We have previously shown that vaccination with tumor-pulsed dendritic cells amplifies neoantigen recognition in ovarian cancer. Here, in a phase 1 clinical study ( NCT01312376 /UPCC26810) including 19 patients, we show that such responses are further reinvigorated by subsequent adoptive transfer of vaccine-primed, ex vivo-expanded autologous peripheral blood T cells. The treatment is safe, and epitope spreading with novel neopeptide reactivities was observed after cell infusion in patients who experienced clinical benefit, suggesting reinvigoration of tumor-sculpting immunity.
Authors
Sara Bobisse, Valentina Bianchi, Janos L. Tanyi, Apostolos Sarivalasis, Edoardo Missiaglia, Rémy Pétremand, Fabrizio Benedetti, Drew A. Torigian, Raphael Genolet, David Barras, Alexandra Michel, Spyridon A. Mastroyannis, Emese Zsiros, Denarda Dangaj Laniti, Zoi Tsourti, Brian J. Stevenson, Christian Iseli, Bruce L. Levine, Daniel E. Speiser, David Gfeller, Michal Bassani-Sternberg, Daniel J. Powell, Carl H. June, Urania Dafni, Lana E. Kandalaft, Alexandre Harari, George Coukos