Design, synthesis and anti-cancer activity of novel 1,2,3-triazole hybrids of erlotinib against cervical cancer via MAPK signaling pathway

Lan Wang & Lizeng Peng et al. · 2025-07-09

Cervical cancer, a common malignant tumor of the female reproductive system, ranks fourth in incidence and mortality among female cancers globally, which highlights the urgent need for new therapeutic agents to improve treatment outcomes. In this study, 16 new erlotinib-1,2,3-triazole derivatives were synthesized via click chemistry and evaluated for their anti-proliferative activities against HeLa cells using the MTT assay. Compound 3h exhibited the most potent antitumor activity, with a half-maximal inhibitory concentration (IC
Links
DOIPubMed
Journal
Scientific Reports
Authors
Lan Wang, Xixi Hou, Mengmeng Huang, Baoyu He, Longfei Mao, Zhengwei Hu, Ling Li, Jingjing Guo, Lizeng Peng
Funding
Key Scientific Research Projects of Universities in Henan Province Grant 23B310001Key Scientific Research Projects of Universities in Henan Province Grant 24A350006Key Scientific Research Projects of Universities in Henan Province Grant 24A350006International Science and Technology Cooperation Project of Henan Province of China Grant 242102520016International Science and Technology Cooperation Project of Henan Province of China Grant 242102520016International Science and Technology Cooperation Project of Henan Province of China Grant 242102520016International Science and Technology Cooperation Project of Henan Province of China Grant 242102520016