Laxaphycins B5 and B6 from the cultured cyanobacterium UIC 10484

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Jimmy Orjala

doi:10.1038/s41429-020-0301-x

Laxaphycins B5 and B6 from the cultured cyanobacterium UIC 10484

Jimmy Orjala · 2020-03-31

Two laxaphycin type-B cyclic dodecapeptides, laxaphycins B5 and B6, were obtained from UIC 10484, a freshwater cf. Phormidium sp. Analysis using the 16S rRNA sequence found UIC 10484 to clade with UIC 10045, a known laxaphycin type-A and -B producer, and MS/MS analysis revealed the presence of two novel laxaphycin type-B compounds. The structures of the metabolites were elucidated using 2D NMR and MS/MS. The absolute configurations of the amino acids were determined by advanced Marfey's analysis. Both metabolites were evaluated against the same three cancer cell lines. The IC

NCI NIH HHS

P01 CA125066

NCCIH NIH HHS

T32 AT007533

U.S. Department of Health & Human Services | NIH | National Cancer Institute

P01CA12506

U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health

T32AT007533

Laxaphycins B5 and B6 from the cultured cyanobacterium UIC 10484

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