Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium
Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race. We evaluated body mass index (BMI) and invasive epithelial ovarian cancer (EOC) risk in a pooled study of case-control and nested case-control studies including AA and White women. We evaluated both young adult and recent BMI (within the last 5 years). Associations were estimated using multi-level and multinomial logistic regression models. The sample included 1078 AA cases, 2582 AA controls, 3240 White cases and 9851 White controls. We observed a higher risk for the non-high-grade serous (NHGS) histotypes for AA women with obesity (OR Obesity contributes to NHGS EOC risk in AA and White women, but risk across racial groups studied differs by HT use and histotype.
Journal
British Journal of CancerInstitutions
Authors
Funding
NHLBI NIH HHS Grant HHSN268201600001CA Follow-up Study for Causes of Cancer in Black WomenA Follow-up Study for Causes of Cancer in Black WomenCancer Research Training and Education CoordinationWomen's Health Initiative Cancer Survivor CohortThe Molecular Epidemiology Of Ovarian CancerNHLBI NIH HHS Grant HHSN268201600002CNHLBI NIH HHS Grant HHSN268201600004CNHLBI NIH HHS Grant HHSN268201600018CExploring factors related to racial disparities in ovarian cancer incidence and survival: the OCWAA consortiumCollaborative Genetic Study of Ovarian Cancer RiskAn assessment of whether aspirin and/or vitamin D improves breast cancer outcomes in Black women and the modifying effect of genetic variantsNHLBI NIH HHS Grant HHSN268201600003CA Follow-up Study for Causes of Illness in Black WomenEpidemiology of Ovarian Cancer in African-American WomenAn assessment of whether aspirin and/or vitamin D improves breast cancer outcomes in Black women and the modifying effect of genetic variantsEpidemiology of Ovarian Cancer in African-American WomenA Follow-up Study for Causes of Illness in Black WomenA Follow-up Study for Causes of Cancer in Black WomenA Follow-up Study for Causes of Cancer in Black WomenMethylation Suicide in Cancer (PQ10)National Institutes of Health Grant R01-CA58598The Molecular Epidemiology Of Ovarian CancerExploring factors related to racial disparities in ovarian cancer incidence and survival: the OCWAA consortiumU.S. Department of Health & Human Services | National Institutes of Health Funding