TL;DR
It is demonstrated that GATA4 suppresses lysosomal acidification and epithelial–mesenchymal transition, while its CRL4B-mediated ubiquitination and degradation in metastatic ovarian cancer cells leads to reduced H3K27ac modification at tumor suppressing genes.
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Authors
Xin Yin, Rufei Gao, Yanqing Geng, Xinyi Mu, Yan Zhang, Yidan Ma, Xuemei Chen, Fei Han, Zhuxiu Chen, Fangfang Li, Junlin He
Funding
the National Natural Science Foundation of China
82303095
Special Funding for Postdoctoral Research Project of Chongqing
CSTB2023NSCQ-BHX0024
the Special Professorship Project of Chongqing Medical
2021-215
