The relationship between human papillomavirus genotype distribution and age and the association with high-grade squamous intraepithelial lesions of the cervix or cervical cancer in Jilin Province, China

Lixia Zhu & Lu Dan et al. · 2025-11-18

Using a retrospective cohort of 21,282 individuals aged 10-89 years (634 males, 20,648 females) from Jilin Province between October 2017 and September 2019, we performed HPV genotyping and colposcopy-directed biopsy to delineate age- and genotype-specific infection patterns. High-risk HPV prevalence peaked in adolescence (≤ 18 years) and declined thereafter, whereas low-risk types showed modest age trends (P < 0.001); women had higher rates than men at every age (P < 0.001). HPV16, 18, 33 and 58 were strongly linked to high-grade squamous intraepithelial lesions or cervical cancer, with adjusted ORs (Model II) of 2.41, 0.53, 2.32 and 1.72, respectively. A U-shaped, nonlinear age relationship emerged, with infection risk threshold ages (fold K) at 26, 42, 30 and 37 years. These findings indicate that HPV vaccination and screening should prioritize women ≤ 26 years and re-engage those > 37 years.
Authors
Lixia Zhu, Peiyao Li, Yingyao Wang, Shuqi Zhang, Haifeng Xu, Juping Zhang, Juan Chen, Jing Ren, Yitong Wu, Yanjin Yao, Yafang Hua, Ping Li, Qin Liu, Lu Dan
Funding

The scientific research project of the Jiangsu Provincial Health and Wellness Commission

Z2021084

The Kunshan Key Research and Development Programme

KSF202101

Suzhou Municipal Health Commission Science and Technology Project.

LCZX202228