Integrated multi-omics identifies a CD54+ iCAF-ITGAL+ macrophage niche driving immunosuppression via CXCL8-PDL1 axis in cervical cancer

Fanghua Chen & Keqin Hua et al. · 2025-10-21

Cervical cancer (CC) remains a formidable clinical challenge, particularly in advanced stages where immune checkpoint blockade yields suboptimal responses. Despite the established role of the tumor microenvironment (TME) in fostering immunosuppression, the precise mechanisms of stroma-immune crosstalk in CC remain elusive. Leveraging single-cell RNA sequencing of 77,221 cells from CC and normal cervical tissues, we uncovered a tumor-enriched subpopulation of inflammatory cancer-associated fibroblasts (iCAFs) marked by elevated CD54 expression (CD54
Links
DOIPubMed
Journal
Molecular Cancer
Authors
Fanghua Chen, Gaigai Bai, Qinqin Liu, Guangping He, Ziyang Ding, Jiali Liang, Nan Wang, Junjun Qiu, Keqin Hua
Funding
National Natural Science Foundation of China Grant 82472993National Natural Science Foundation of China Grant 82173188Medical Innovation Research of Shanghai Science and Technology Grant 21Y11906900Medical Innovation Research Special Project under the Science and Technology Innovation Action Plan of the Shanghai Municipal Science and Technology Commission Grant 22Y31900500