SELP+ TEC:CD8+ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer

Qingyu Huang & Chao Liu et al. · 2025-02-03

P-selectin (SELP) expression in tumor cells has been implicated in promoting tumor progression and treatment resistance across various cancers. However, our prior study identified SELP expression in a specific subpopulation of endothelial cells within cervical cancer (CC) and potentially linked to anti-cancer immune response. The precise mechanisms by which SELP influences anti-cancer immunity and its involvement in radiotherapy response in CC, however, remain elusive. To address these gaps, this study analyzed tumor tissue samples from 205 CC patients undergoing radiotherapy, scRNA-seq data from 42,159 cells of eight patients, and bulk RNA-sequencing data from 187 radiotherapy-treated patients. The results revealed that elevated SELP expression in tumor endothelial cells (TECs) was significantly correlated with improved survival outcomes in patients treated with radiotherapy. The SELP
Authors
Qingyu Huang, Wenhui Yang, Fuhao Wang, Rui Huang, Qian Wang, Xiaohui Li, Tianyu Lei, Shengqin Yue, Wenxue Zou, Qi An, Jinbo Yue, Qinyong Hu, Chao Liu
Funding

National Natural Science Foundation of China

82272753

National Natural Science Foundation of China

82403773

Shandong Provincial Natural Science Foundation

ZR2021LZL002

Shandong Provincial Natural Science Foundation

ZR2021QH006

Bethune Cancer Radiotherapy Translational Medicine Research Fund

flzh202103

The Key Research and Development Program of Shandong (Major Science & Technology Innovation Project)

2021SFGC05012021

Postdoctoral Fellowship Program of CPSF

GZB20230041

The Key Research and Development Program of Shandong

2021SFGC05012021