Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study

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doi:10.1186/s12916-026-04637-x

Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study

Ga Won Yim & Hee Seung Kim et al. · 2026-02-02

1Citations

Links

DOI PubMed

Journal

BMC Medicine

TL;DR

Intravenous high-dose selenium safely failed to reduce grade 1 or more CIPN, whereas it reduced grade 2 or more motor dysfunction during chemotherapy in patients with PSROC, especially those with PSROC, especially those over 60 years.

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Authors

Ga Won Yim, Kyung Hee Han, Soon Tae Lee, Maria Lee, Seung Mee Lee, Hee Seung Kim

Funding

Commercializations Promotion Agency for R and D Outcomes Grant 2710019525