Restricted spectrum imaging and diffusion kurtosis imaging for assessing lymph node metastasis in cervical cancer: a histogram analysis-based study
Jiayin Pan & Meiyun Wang et al. · 2025-11-25
Restricted spectrum imaging (RSI) and diffusion kurtosis imaging (DKI) provide comprehensive characterization of tumor microstructural features; however, the clinical utility for evaluating lymph node metastasis (LNM) in cervical cancer (CC) warrants further investigation. A total of 71 CC patients were enrolled, including 30 with negative LNM and 41 with positive LNM, all of whom underwent pelvic MRI examination. Chi-square tests, independent sample t tests, and Mann‒Whitney U tests were employed to calculate and compare histogram parameters from the DKI (D, K) and RSI (f Compared with the LNM-positive group, the LNM-negative group had higher D DKI and RSI, along with their corresponding histogram parameters, demonstrate outstanding potential for predicting LNM in CC patients. Moreover, the combination of maximum diameter, maximum diameter and DKI_D