Risk stratification and conservative management of women aged 25–40 years with cervical intraepithelial neoplasia grade 2(CIN2)

Huanhua Wang & Ping Jin · 2025-05-14

3Citations
Cervical intraepithelial neoplasia grade 2 (CIN2) can progress to CIN3 or worse (CIN3 We conducted a retrospective observational study of 307 women aged ≤ 40 years, diagnosed with CIN2 via colposcopy-guided punch biopsy where the squamocolumnar junction was visible, and who underwent LEEP within three months. We compared the diagnoses from punch biopsies with the histology of the LEEP specimens and developed a stratified management algorithm based on identified risk factors. The risk of CIN3 Patients aged 25-40 years with CIN2 diagnosed in punch biopsy exhibited a substantial risk of CIN3
TL;DR

Patients aged 25–40 years with CIN2 diagnosed in punch biopsy exhibited a substantial risk of CIN3+ in LEEP specimens, warranting consideration for surgical intervention, particularly in those with HPV16/18 and HSIL cytology.

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