Polyphyllin I inhibits ovarian cancer growth by inducing G0/G1 phase arrest and inhibiting the c-Myc signaling pathway

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doi:10.1007/s12032-025-02824-z

Polyphyllin I inhibits ovarian cancer growth by inducing G0/G1 phase arrest and inhibiting the c-Myc signaling pathway

Qing Tang & Yongxia Zhu et al. · 2025-06-12

1Citations

Links

DOI PubMed

Journal

Medical Oncology

TL;DR

The results indicate that PPI demonstrated dose- and time-dependent anti-proliferative effects on ovarian cancer cell lines, indicating its potential as a treatment option for ovarian cancer.

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Authors

Qing Tang, Kun Huang, Mengjie Li, Ziqiao Zhao, Yuanle Deng, Yueqi Zuo, Ningyu Wang, Yongxia Zhu

Funding

Sichuan Science and Technology Program Grant 2025ZNSFSC1858 and 2024NSFSC1742 Natural Science Basic Research Plan in Shaanxi Province of China Grant 2023-JC-QN-0877 Chengdu Science and Technology Program Grant 2024-YF05-00783-SN Sichuan Science and Technology Program Grant 2025ZNSFSC1858 and 2024NSFSC1742