Curcumin-gold nanoshell mediated near-infrared irradiation on human ovarian cancer cell: in vitro study
3Citations
Ovarian cancer is considered a predominant female reproductive malignancy and poses a significant threat due to its 80-90% fatality rate. The typical approach involves surgery and chemotherapy, which due to problems such as drug resistance, encourage researchers to use new methods such as nanotechnology. The current study introduces a novel strategy: leveraging Curcumin-Gold Nanoshells (Cur-AuNShs) to combat chemotherapy's adverse effects and overcome drug resistance through hyperthermia mediation. Gold-based nanoparticles that absorb laser have shown the potential to target and treat cancer selectively through highly efficient light-to-heat conversion. This experimental study focused on the synthesis of AuNShs and their subsequent conjugation with Cur. The gold shell coverage on the surfaces of silica nanoparticles was examined using UV-VIS spectroscopy and transmission electron microscopy (TEM). Dynamic light scattering (DLS) and Zeta potential analysis were employed to evaluate the stability of particle size and surface charge. Human ovarian carcinoma cell lines (SKOV-3) were treated with a combination of Cur (15 μM) and AuNShs (75 μM), under the activation of near-infrared (NIR) laser irradiation at a power of 2.5 W/cm