This study aimed to identify the most appropriate volume of interest (VOI) setting in prognostic prediction using pretreatment magnetic resonance imaging (MRI) radiomic analysis for cervical cancer (CC) treated with definitive radiotherapy. The study participants were 87 patients who had undergone pretreatment MRI and definitive radiotherapy for CC. VOI VOI expansion improved AUC-ROCs compared with the predictive models of VOI Recurrence could be predicted with high accuracy using expanded VOI for CC treated with definitive radiotherapy, suggesting that including the pathological characteristics of invasive margins in radiomics may improve predictive ability.