Selective expansion of TCF7-expressing tumor-reactive T cell subpopulations during ovarian tumor-infiltrating T cell production ex vivo

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doi:10.1007/s11427-025-2958-3

Selective expansion of TCF7-expressing tumor-reactive T cell subpopulations during ovarian tumor-infiltrating T cell production ex vivo

Dingfeng Liu & Chen Dong et al. · 2025-07-08

1Citations

Tumor-infiltrating lymphocyte (TIL) therapy was recently approved for melanoma patients; however, the dynamic changes in T cell subpopulations during TIL production remain poorly understood. Here, we analyzed epithelial ovarian cancer samples at various stages of ex vivo TIL culture using paired single-cell RNA and TCR sequencing. We also assessed the expansion potential and tumor reactivity of the identified TIL subpopulations. Single-cell transcriptomic analysis revealed that CD8

Links

DOI PubMed

Journal

Science China Life Sciences

TL;DR

Findings highlight the selective expansion of tumor-reactive TCF7+ T cells during TIL culture and suggest that CCR7 and CD200 serve as important surface markers for generating stem-like, tumor-reactive cells, potentially improving TIL therapy in cancers.

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Authors

Dingfeng Liu, Ting Zhang, Qinli Sun, Dongli Cai, Yanan Lou, Genyu Wang, Bowen Xie, Yicheng Zhu, Chong Wang, Zhouping Lu, Chenfei Liu, Yuan Li, Xi Zhang, Tianhui He, Jing Hao, Xinyi Guo, Jiaming Li, Xiaowei Xi, Ling Ni, Hongyan Guo, Jing Ge, Liping Jin, Chen Dong