Folic Acid-Doxorubicin-Double-Functionalized-Lipid-Core Nanocapsules: Synthesis, Chemical Structure Elucidation, and Cytotoxicity Evaluation on Ovarian (OVCAR-3) and Bladder (T24) Cancer Cell Lines

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doi:10.1007/s11095-021-02989-y

Folic Acid-Doxorubicin-Double-Functionalized-Lipid-Core Nanocapsules: Synthesis, Chemical Structure Elucidation, and Cytotoxicity Evaluation on Ovarian (OVCAR-3) and Bladder (T24) Cancer Cell Lines

Rodrigo Cé & Adriana Raffin Pohlmann et al. · 2021-02-19

Folic acid-doxorubicin-double-functionalized-lipid-core nanocapsules (LNC-CS- LNC-CS- The presence of lecithin allows the formation of nanocapsules with a lower tendency of agglomeration, narrower size distributions, and smaller diameters due to an increase in hydrogen bonds at the surface. LNC- Lecithin favored the increase of hydrogen bonds at the surface, leading to a lower tendency of agglomeration for nanocapsules. LNC-CS-

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DOI PubMed

Journal

Pharmaceutical Research

Authors

Rodrigo Cé, Vladimir Lavayen, Gabriela Klein Couto, João Guilherme Barreto De Marchi, Barbara Zoche Pacheco, Letícia Antunes Natividade, Tiago Ost Fracari, Taiane Medeiro Ciocheta, Aline de Cristo Soares Alves, Denise Soledade Jornada, Silvia Stanisçuaski Guterres, Fabiana Seixas, Tiago Collares, Adriana Raffin Pohlmann