Oxidative Stress-Related KEAP1 and NRF2 Genes Contributed to the Risk of Epithelial Ovarian Cancer
6Citations
The NRF2/KEAP1 signaling pathway, crucial for cellular defense against oxidative stress, may influence epithelial ovarian cancer (EOC) risk. This study investigates the association between KEAP1 gene polymorphisms and EOC risk in Han Chinese individuals, while exploring correlations between these genetic variants and serum levels of KEAP1 and NRF2 proteins. We conducted a case-control study involving 1962 EOC patients and 2057 controls, genotyping ten tag single-nucleotide polymorphisms (SNPs) in KEAP1. Serum KEAP1 and NRF2 levels were measured using ELISA. Genetic association analyses and ANOVA were employed to assess relationships between SNPs, EOC risk, and serum protein levels. Notably, only SNP rs3177696 in KEAP1 showed a significant association with EOC risk. The G allele of rs3177696 conferred a protective effect against EOC (OR [95% CI] = 0.58 [0.47-0.72], P = 2.91 × 10