Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling

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Lanmei Chen

doi:10.1007/s00775-021-01894-4

Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling

Lanmei Chen · 2021-08-30

10Citations

Two new cyclometalated Ru(II)-β-carboline complexes, [Ru(dmb)

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JBIC Journal of Biological Inorganic Chemistry

TL;DR

Further research revealed that RuβC-3 could deactivate the ERK/Akt signaling pathway thus inhibiting HeLa cell invasion and migration, and inducing apoptosis, and the developed Ru(II) complexes have great potential on developing novel low-toxic anticancer drugs.

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Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling

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