Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status
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An in-depth analysis of the tumor microenvironment of ovarian cancer is needed. The purpose of this study was to elucidate the architecture of the immune microenvironment of high-grade serous ovarian cancers (HGSCs) with or without BRCA1 and BRCA2 mutations. A cohort of highly annotated HGSC patients with known germline BRCA1 and BRCA2 status was selected, and pretreatment tumor tissue specimens were analyzed with a multiplexed staining technique aimed at detecting lymphocytes, macrophages, and fibroblasts in the whole tumor area and in specific regions including epithelium, stroma, and perivascular areas. BRCA1- or BRCA2-mutated tumors showed a more immunogenic microenvironment, characterized by a higher abundance of CD8 This study reveals substantial differences between the immune microenvironment composition of germline BRCA-mutated and BRCA wild-type HGSC.
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Cancer Center Support GrantTargeted therapeutics for ovarian cancer and its microenvironment - treatment and theoretical modelingCore 1: Pathology CoreHarnessing the power of exosomes for non-coding RNA deliveryDevelopment of Novel Ovarian Cancer Biomarkers for Early Detection AlgorithmsSingle Cell Spatial Analysis in TissueCancer Center Support Grantthe MD Anderson Ovarian Cancer SPORE Grant P50 CA217685,R35 CA209904, U01 CA213759Cancer Center Support GrantAmerican Cancer Society FundingFrank McGraw Memorial Chair in Cancer Research Funding