Added-value of dynamic contrast-enhanced MRI on prediction of tumor recurrence in locally advanced cervical cancer treated with chemoradiotherapy
To evaluate whether the DCE-MRI derived parameters integrated into clinical and conventional imaging variables may improve the prediction of tumor recurrence for locally advanced cervical cancer (LACC) patients following concurrent chemoradiotherapy (CCRT). Between March 2014 and November 2019, 79 consecutive LACC patients who underwent pelvic MRI examinations with DCE-MRI sequence before treatment were prospectively enrolled. The primary outcome was disease-free survival (DFS). DCE-MRI derived parameters, conventional imaging, and clinical factors were collected. Univariate and multivariate Cox hazard regression analyses were performed to evaluate these parameters in the prediction of DFS. The independent and prognostic interested variables were combined to build a prediction model compared with the clinical International Federation of Gynecological (FIGO) staging system. Lymph node metastasis (LNM) and the mean value of v The v Lower v