Digital spatial profiling reveals additive effects of triple therapy on tumor microenvironment: anti-PD-L1, anti-VEGF, and PARP inhibition in mouse models

Akihiko Ueda & Masaki Mandai et al. · 2026-02-07

TL;DR

Triple therapy may overcome immune-desert ovarian cancer through additive HEV formation, enhancing cytotoxic CD8’+ T cell infiltration into the tumor.

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Authors
Akihiko Ueda, Ryusuke Murakami, Kentaro Ishida, Kohei Hamada, Jumpei Ogura, Shunsuke Kawahara, Yuka Mise, Yuko Hosoe, Masamichi Sugimoto, Daiko Wakita, Taito Miyamoto, Rin Mizuno, Mana Taki, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Masaki Mandai