“Cancer Integrin” αvβ6 Imaging With 68Ga-Trivehexin PET/CT in Assessment of Ovarian Carcinoma

Abstract

Peritoneal cancer index is an integral parameter for preoperative assessment of peritoneal disease. Current imaging modalities including ¹⁸F-FDG PET/CT, though superior to CT, underestimate the disease extent, mainly due to its high physiological background activity. Novel “cancer integrin” targeting imaging with ⁶⁸Ga-trivehexin demonstrates limited physiological activity in the abdomen with superior target-to-background ratio than ¹⁸F-FDG PET/CT. Thus, we describe the first case demonstrating potential utility of novel “cancer integrin” αvβ6 imaging agent ⁶⁸Ga-trivehexin for assessment of disease burden in advanced epithelial ovarian cancer.