Synchronous Endometrial Cancer Detected on 68Ga-DOTATATE PET/CT

Abstract

A 50-year-old woman with history of metastatic neuroendocrine tumor underwent a follow-up PET/CT with ⁶⁸Ga-DOTATATE. An enlarged uterus with diffuse increased uptake warranted further investigation with an MRI that showed mass-like thickening of the endometrium, T2 hyperintensity, lobulated contour, and invasion of more than 50% of the myometrium. Biopsy revealed endometrial carcinoma with mucinous features. Mild to moderate uptake of the ⁶⁸Ga-DOTATATE by the uterus can be a normal physiological finding; however, it should prompt further investigation, particularly in a postmenopausal woman with concerning imaging or clinical findings.