KLC3 activates PI3K/AKT signaling and promotes ovarian cancer cell proliferation and migration through COL3A1

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doi:10.3892/or.2025.8900

KLC3 activates PI3K/AKT signaling and promotes ovarian cancer cell proliferation and migration through COL3A1

Jing Yang & Yulan Li et al. · 2025-04-17

3Citations

Ovarian cancer (OC) is a prevalent malignancy; however, the role of kinesin light chain 3 (KLC3) in OC remains unclear. The present study conducted a comprehensive investigation of KLC3 using bioinformatics analysis, as well as

Links

DOI PubMed

Journal

Oncology Reports

TL;DR

KLC3 acts as an oncogene by influencing COL3A1 expression to promote the proliferation and migration of OC cells in vivo and in vitro, underscoring the pivotal role of KLC3 in tumor progression and metastasis.

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Authors

Jing Yang, Rongxia He, Xiaoling Zhang, Xing Wang, Min Liu, Xiaolong Liu, Yulan Li