Fumarate hydratase functions as a tumor suppressor in endometrial cancer by inactivating EGFR signaling

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doi:10.3892/or.2023.8620

Fumarase hydratase (FH) is an enzyme that catalyzes the reversible hydration and dehydration of fumarate to malate in the tricarboxylic acid cycle. The present study addressed the role of FH in endometrial cancer and clinically observed that the expression of FH was significantly lower in endometrial cancer tissues compared with normal endometrial tissues and, furthermore, that the decreased FH expression in endometrial cancer tissues was significantly associated with increased tumor size and lymph node metastasis. Further analysis in

Fumarate hydratase functions as a tumor suppressor in endometrial cancer by inactivating EGFR signaling

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