Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review

Jiaying Cai & Jinhao Zeng et al. · 2023-06-29

Ovarian cancer (OC) is one of the most common types of cancer in women with a high mortality rate, and the treatment of OC is prone to high recurrence rates and side effects. Scutellaria baicalensis (SB) is a herbal medicine with good anti-cancer activity, and several studies have shown that SB and its flavonoids have some anti-OC properties. This paper elucidated the common pathogenesis of OC, including cell proliferation and cell cycle regulation, cell invasion and metastasis, apoptosis and autophagy, drug resistance and angiogenesis. The mechanisms of SB and its flavonoids, wogonin, baicalein, baicalin, Oroxylin A, and scutellarein, in the treatment of OC, are revealed, such as wogonin inhibits proliferation, induces apoptosis, inhibits invasion and metastasis, and increases the cytotoxicity of the drug. Baicalein also inhibits vascular endothelial growth factor (VEGF) expression etc. Analyzing their advantages and disadvantages in treating OC provides a new perspective on the role of SB and its flavonoids in OC treatment. It serves as a resource for future OC research and development.

Links
DOIPubMed
Journal
Molecules
Authors
Jiaying Cai, Qichao Hu, Zhelin He, Xiaoyan Chen, Jian Wang, Xiang Yin, Xiao Ma, Jinhao Zeng
Funding
Program of Science and Technology Department of Sichuan Province Grant 2023NSFSC0687Program of Science and Technology Department of Sichuan Province Grant 2023YFS0476Program of Science and Technology Department of Sichuan Province Grant QJRC2022028Program of Science and Technology Department of Sichuan Province Grant QJJJ2022010Program of Science and Technology Department of Sichuan Province Grant 2022KTZ016Program of Science and Technology Department of Sichuan Province Grant 22-B09Xinglin Scholar Research Promotion Project of Chengdu University of TCM Grant 2023NSFSC0687Xinglin Scholar Research Promotion Project of Chengdu University of TCM Grant 2023YFS0476Xinglin Scholar Research Promotion Project of Chengdu University of TCM Grant QJRC2022028Xinglin Scholar Research Promotion Project of Chengdu University of TCM Grant QJJJ2022010Xinglin Scholar Research Promotion Project of Chengdu University of TCM Grant 2022KTZ016Xinglin Scholar Research Promotion Project of Chengdu University of TCM Grant 22-B09Major scientific research problems and critical topics of medical technology problems of China Medical Education Association Grant 2023NSFSC0687Major scientific research problems and critical topics of medical technology problems of China Medical Education Association Grant 2023YFS0476Major scientific research problems and critical topics of medical technology problems of China Medical Education Association Grant QJRC2022028Major scientific research problems and critical topics of medical technology problems of China Medical Education Association Grant QJJJ2022010Major scientific research problems and critical topics of medical technology problems of China Medical Education Association Grant 2022KTZ016Major scientific research problems and critical topics of medical technology problems of China Medical Education Association Grant 22-B09“The Hundred Talents Program” of the Hospital of the Chengdu University of Traditional Chinese Medicine Grant 2023NSFSC0687“The Hundred Talents Program” of the Hospital of the Chengdu University of Traditional Chinese Medicine Grant 2023YFS0476“The Hundred Talents Program” of the Hospital of the Chengdu University of Traditional Chinese Medicine Grant QJRC2022028“The Hundred Talents Program” of the Hospital of the Chengdu University of Traditional Chinese Medicine Grant QJJJ2022010“The Hundred Talents Program” of the Hospital of the Chengdu University of Traditional Chinese Medicine Grant 2022KTZ016“The Hundred Talents Program” of the Hospital of the Chengdu University of Traditional Chinese Medicine Grant 22-B09