Primary uterine large granular lymphocyte lymphoma in an ovariectomised cat

Primary uterine lymphoma is an extremely rare disease. An 11‐year‐old spayed female domestic short‐haired cat presented with a 3‐month history of mucopurulent vaginal discharge, lethargy, acute vomiting and constipation. Physical examination revealed vulvar swelling, purulent discharge and a mass in the mid‐caudal abdomen. A CT scan identified a large uterine mass, displacing the colon dorsally and the urethra ventrally. A hysterectomy was performed. Histology and immunohistochemistry confirmed a T‐cell uterine transmural medium to large cell lymphoma. One‐month post‐surgery, an abdominal ultrasound showed thickening of the jejunal loops, enlarged lymph nodes and nodular peritoneal lesions at the surgical site. Cytology raised suspicion of large granular lymphocyte lymphoma, confirmed by anti‐Granzyme B immunohistochemistry on the uterine tissue specimen. The final diagnosis was primary uterine large granular lymphocyte lymphoma, marking the first reported case in small animal oncology.