Gadolinium-Based Nanoparticles Sensitize Ovarian Peritoneal Carcinomatosis to Targeted Radionuclide Therapy

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doi:10.2967/jnumed.123.265418

Gadolinium-Based Nanoparticles Sensitize Ovarian Peritoneal Carcinomatosis to Targeted Radionuclide Therapy

Clara Diaz Garcia-Prada & Jean-Pierre Pouget et al. · 2023-12-01

12Citations

Ovarian cancer (OC) is the most lethal gynecologic malignancy (5-y overall survival rate, 46%). OC is generally detected when it has already spread to the peritoneal cavity (peritoneal carcinomatosis). This study investigated whether gadolinium-based nanoparticles (Gd-NPs) increase the efficacy of targeted radionuclide therapy using [

Links

DOI PubMed

Journal

Journal of Nuclear Medicine

TL;DR

Targeted radionuclide therapy can be combined with Gd-NPs to increase the therapeutic effect and reduce the injected activities, and this combination could be a new therapeutic approach for patients with ovarian peritoneal carcinomatosis.

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Authors

Clara Diaz Garcia-Prada, Léna Carmes, Salima Atis, Ali Parach, Alejandro Bertolet, Marta Jarlier, Sophie Poty, Daniel Suarez Garcia, Wook-Geun Shin, Stanislas Du Manoir, Jan Schuemann, Olivier Tillement, François Lux, Julie Constanzo, Jean-Pierre Pouget

Funding

Radiation dosimetry for alpha-particle radiopharmaceutical therapy and application to pediatric neuroblastoma

NCI NIH HHS

R00 CA267560