First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic

Mathias Loft & Andreas Kjaer et al. · 2022-05-19

Tissue factor (TF) expression in cancers correlates with poor prognosis. Recently, the first TF-targeted therapy was approved by the U.S. Food and Drug Administration for cervical cancer. To unfold the potential of TF-targeted therapies, correct stratification and selection of patients eligible for treatments may become important for optimization of patient outcomes. TF-targeted PET imaging based on
Authors
Mathias Loft, Camilla Christensen, Malene M. Clausen, Esben A. Carlsen, Carsten P. Hansen, Niels Kroman, Seppo W. Langer, Claus Høgdall, Jacob Madsen, Nic Gillings, Carsten H. Nielsen, Thomas L. Klausen, Søren Holm, Annika Loft, Anne K. Berthelsen, Andreas Kjaer