Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1–Targeted 18F-Fluorthanatrace PET Images of Ovarian Cancer

Anthony J. Young & Robert K. Doot et al. · 2021-04-16

The poly-(adenosine diphosphate-ribose) polymerase (PARP) family of proteins participates in numerous functions, most notably the DNA damage response. Cancer vulnerability to DNA damage has led to development of several PARP inhibitors (PARPi). This class of drugs has demonstrated therapeutic efficacy in ovarian, breast, and prostate cancers, but with variable response. Consequently, clinics need to select patients likely to benefit from these targeted therapies. In vivo imaging of
Authors
Anthony J. Young, Austin R. Pantel, Varsha Viswanath, Tiffany L. Dominguez, Mehran Makvandi, Hsiaoju Lee, Shihong Li, Erin K. Schubert, Daniel A. Pryma, Michael D. Farwell, Robert H. Mach, Fiona Simpkins, Lilie L. Lin, David A. Mankoff, Robert K. Doot