PFKFB3 Regulates the Growth and Migration of Ovarian Cancer Cells through Pyroptosis and Warburg Effect Progression
<p>Ovarian cancer is one of the most common malignant tumors in female reproductive organs. Its incidence rate is second only to uterine body cancer and cervical cancer, posing a serious threat to women's health. Herein, we explored that <i>PFKFB3</i> in cancer progression of ovarian cancer and its underlying mechanism. All the serum samples from ovarian cancer were collected by our hospital. <i>PFKFB3</i> mRNA expressions in patients with ovarian cancer and ovarian cancer cell lines were up-regulated. <i>PFKFB3</i> protein expressions in ovarian cancer cells were induced. ovarian cancer patients with high <i>PFKFB3</i>expression had lower survival rate. The <i>PFKFB3</i>gene promoted cell proliferation and EDU cells, and increased cell metastasis of ovarian cancer. Si-<i>PFKFB3</i> reduced cell proliferation and EDU cells, and decreased cell metastasis of ovarian cancer. <i>PFKFB3</i> gene up-regulation reduced caspase-3/9 activity levels of ovarian cancer. Si-<i>PFKFB3</i> also promoted caspase-3/9 activity levels of ovarian cancer. <i>PFKFB3</i> gene promoted Warburg effect progression of ovarian cancer. <i>PFKFB3</i> gene reduced NLRP3-induced pyroptosis of ovarian cancer. <i>PFKFB3</i> suppressed NLRP3 expression. NLRP3 was one target spot for <i>PFKFB3</i> on pyroptosis of ovarian cancer. Taken together, we conclude that <i>PFKFB3</i> suppressed NLRP3 axis to reduce pyroptosis and increase Warburg effect progression of ovarian cancer, and provide molecular insight into the mechanisms by which the <i>PFKFB3</i> regulates pyroptosis of ovarian cancer.
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