Prospective Single-Arm Study of Endocrine Therapies With Ovarian Function Suppression in Premenopausal Node-Positive Early Breast Cancer Patients With Low Genomic Risk (INTERSTELLAR Trial, KBCSG-25)

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Sung Gwe Ahn; Sung Hoon Sim; Taewoo Kang; Eun-Kyu Kim; Jeong Eon Lee; Hyeong-Gon Moon; Jee Hyun Ahn; Woosung Lim; Hyun Jo Youn; Hyun-Ah Kim; Chang Ik Yoon; Jisun Kim; Byeongju Kang; Min Ho Park; Su Hwan Kang; Lee Su Kim; Soong June Bae; Yoonwon Kook; Kwan Ho Lee; Han-Byoel Lee; Wonshik Han; Yeon Hee Park

doi:10.4048/jbc.2025.0181

Prospective Single-Arm Study of Endocrine Therapies With Ovarian Function Suppression in Premenopausal Node-Positive Early Breast Cancer Patients With Low Genomic Risk (INTERSTELLAR Trial, KBCSG-25)

Sung Gwe Ahn & Yeon Hee Park et al. · 2026-01-30

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Journal

Journal of Breast Cancer

TL;DR

The results may establish evidence supporting the omission of adjuvant chemotherapy in premenopausal women with low genomic risk scores and limited nodal involvement, potentially reducing treatment-related morbidity while preserving comparable oncologic outcomes.

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Institutions

Yonsei University National Cancer Center Pusan National University Seoul National University Bundang Hospital Sungkyunkwan University Seoul National University Ewha Womans University Mokdong Hospital Jeonbuk National University Korea Institute Of Radiological And Medical Sciences Catholic University Of Korea University Of Ulsan Kyungpook National University Chilgok Hospital Chonnam National University Hwasun Hospital Yeungnam University College Chung Ang University Gwangmyeong Hospital Kangbuk Samsung Hospital

Funding

Korean Breast Cancer Study Group Funding DCGen Co. Ltd. Funding

Prospective Single-Arm Study of Endocrine Therapies With Ovarian Function Suppression in Premenopausal Node-Positive Early Breast Cancer Patients With Low Genomic Risk (INTERSTELLAR Trial, KBCSG-25)

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Journal

TL;DR

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Funding