Determining the maximum tolerated dose of paclitaxel combined with fixed dose of cisplatin for hyperthermic intraperitoneal chemotherapy in ovarian cancer: A multicenter phase I trial

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doi:10.1016/j.ygyno.2023.12.019

Determining the maximum tolerated dose of paclitaxel combined with fixed dose of cisplatin for hyperthermic intraperitoneal chemotherapy in ovarian cancer: A multicenter phase I trial

Miao-fang Wu & Jing Li et al. · 2023-12-30

6Citations

To determine the maximum tolerated dose (MTD) of paclitaxel combined with a fixed dose of cisplatin (75 mg/m This multicenter Phase I trial employed a Bayesian Optimal Interval (BOIN) design. The MTD was determined to have a target dose-limiting toxicity (DLT) rate of 25%. The starting dose was 175 mg/m Twenty-one patients participated in this study. Among the three evaluable patients who received 150 mg/m Paclitaxel, when combined with a fixed dose of cisplatin (75 mg/m

Links

DOI PubMed

Journal

Gynecologic Oncology

TL;DR

Paclitaxel, when combined with a fixed dose of cisplatin (75 mg/m2), can be safely administered intraperitoneally at a dose of 175 mg/m2 in patients with ovarian cancer who received HIPEC following cytoreductive surgery.

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Authors

Miao-fang Wu, Xiao-yu Cheng, Dong-yan Wang, Yu-ting Lai, Hui Li, Yan-fang Ye, Yong-pai Peng, Qing Chen, Bing-zhong Zhang, Zhong-qiu Lin, Jing Li

Funding

Medical Science and Technology Foundation of Guangdong Province Funding Basic and Applied Basic Research Foundation of Guangdong Province Grant 2021A1515111177 Basic and Applied Basic Research Foundation of Guangdong Province Grant 2021A1515220142 Basic and Applied Basic Research Foundation of Guangdong Province Grant 2023A1515012647 Beijing Xisike Clinical Oncology Research Foundation Funding