ZNF671 methylation test in cervical scrapings for cervical intraepithelial neoplasia grade 3 and cervical cancer detection

Qing Li · 2023-08-08

22Citations
Effective triage of high-risk human papillomavirus (hrHPV)+ women is warranted to avoid unnecessary referral and overtreatment. Molecular triage tests have recently begun to impact cervical intraepithelial neoplasia grade 3 (CIN3) or cervical cancer (CC), termed CIN3+, detection. We find that zinc finger protein 671 methylation (ZNF671
Links
DOIPubMed
Journal
Cell Reports Medicine
TL;DR

It is found that zinc finger protein 671 methylation test has superior performance for CIN3+ detection in all single molecular triage tests, including HPV16/18 genotyping, paired box gene 1 methylation (PAX1m), and ZNF671m, in the training set.

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Institutions
Xiangya Hospital Central South University
Authors
Qing Li
Funding
National Natural Science Foundation of China Grant 81973401National Natural Science Foundation of China Grant CN112941189ANational Natural Science Foundation of China Grant ZNF671