An "on-off" electrochemical immunosensor for the detection of the glycan antigen CA125 by amplification signals using electropositive COFs
Cancer Antigen 125 (CA125), is a high molecular weight mucinous glycoprotein found on the surface of ovarian cancer cells. Generally, 90 % of women may appear a high concentration of CA125 when they got the cancer; thus, CA125 can act as a marker for ovarian cancer diagnosis and therapeutic evaluation. COFs have been widely used for disease detection due to their structural stability, high loading capacity and biocompatibility. However, the limited variety of electroactive COFs used as signal probes, fewer enriched signaling molecules, weaker electrical signals generated, and higher oxidation or reduction potentials of electroactive substances, a series of side reactions are easily triggered causing serious interference. To solve the above problems, [Fe(CN)6]