Unravelling the association between sleep traits and reproductive cancers: A systematic review and meta-analysis
Sleep traits (duration, insomnia, chronotype, snoring) are modifiable lifestyle factors that may influence cancer risk, but their association with reproductive cancers remains unclear. We systematically searched PubMed, Scopus, and Web of Science (until 09/2024) for observational studies investigating associations between sleep traits and reproductive cancers (including breast, prostate, endometrial, epithelial ovarian). We extracted estimates from maximally adjusted models and performed random-effects and dose-response meta-analyses. This study included 62 observational studies (45 cohort, 17 case-control) from 55 publications, but cohorts were primarily considered in interpretation. Compared to a morning chronotype, evening chronotype was associated with higher risk of breast cancer (HR = 1.12; 95 %CI: 1.07-1.17; I