Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA

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Hong-Feng Zhang

doi:10.1016/j.redox.2023.102975

Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA

Hong-Feng Zhang · 2023-11-29

97Citations

1Influential

Endometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m

Links

DOI PubMed

Journal

Redox Biology

TL;DR

Targeting the NSUN2/SLC7A11 axis inhibited tumor growth by increasing lipid peroxidation and ferroptosis of EC cells both in vitro and in vivo.

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Institutions

Huazhong University Of Science And Technology

Authors

Hong-Feng Zhang