ZNF671 methylation is a potential regression predictor of cervical intraepithelial neoplasia grade 3 in the colposcopy-to-conization interval
Despite the high risk of cervical intraepithelial neoplasia grade 3 (CIN3) progressing to cervical cancer, approximately 50 percent of CIN3 lesions were overtreated. Furthermore, CIN3 patients who underwent surgery experienced complications and adverse obstetric outcomes. Therefore, exploring reliable biomarkers to differentiate regressing CIN3 lesions from persistent ones is imperative to preserve female fertility. This study evaluated the association between the methylation level of zinc finger protein 671 (ZNF671 In the analysis of 127 cervical scraping cells from CIN3 patients, negative ZNF671 These results support that ZNF671