4-Hydroxyderricin from Angelica keiskei promotes the stability of BRCA1 in triple-negative breast cancer cells through inhibition of cathepsin S

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doi:10.1016/j.phytochem.2026.114805

4-Hydroxyderricin from Angelica keiskei promotes the stability of BRCA1 in triple-negative breast cancer cells through inhibition of cathepsin S

Isoo Youn & Eun Kyoung Seo et al. · 2026-02-03

Links

DOI PubMed

Journal

Phytochemistry

TL;DR

Combined therapy with compound 12 can enhance BRCA1 function and improve chemotherapeutic efficacy in TNBC patients with wild-type BRCA1, and this study highlights CTSS inhibition as a promising therapeutic strategy for TNBC patients with wild-type BRCA1.

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Authors

Isoo Youn, Hyelim Oh, Taeeun Kim, Sumin Park, Yun-Seo Kil, Soosung Kang, Yun-Sil Lee, Eun Kyoung Seo

Funding

Ministry of Education Grant RS-2023-00243759 National Research Foundation of Korea Funding Military Institute of Science and Technology Grant 2021R1A2C1003350 Military Institute of Science and Technology Grant 2018R1A5A2025286