Nanoaggregate-forming lipid-conjugated AS1411 aptamer as a promising tumor-targeted delivery system of anticancer agents in vitro

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doi:10.1016/j.nano.2021.102429

Nanoaggregate-forming lipid-conjugated AS1411 aptamer as a promising tumor-targeted delivery system of anticancer agents in vitro

Josué Carvalho & Carla Cruz et al. · 2021-06-24

Nanoparticles offer targeted delivery of drugs with minimal toxicity to surrounding healthy tissue and have great potential in the management of human papillomavirus (HPV)-related diseases. We synthesized lipid-modified AS1411 aptamers capable of forming nanoaggregates in solution containing Mg

Links

DOI PubMed

Journal

Nanomedicine: Nanotechnology, Biology and Medicine

Authors

Josué Carvalho, Jéssica Lopes-Nunes, Brune Vialet, Tiago Rosado, Eugenia Gallardo, João Vale, Catarina Eloy, Sofia Ferreira, Rita Palmeira-de-Oliveira, Maria Paula Cabral Campello, António Paulo, Philippe Barthélémy, Jean-Louis Mergny, Gilmar F. Salgado, João A. Queiroz, Andrew D. Ellington, Carla Cruz

Funding

European Regional Development Fund Grant CZ.02.1.01/0.0/0.0/15_003/0000477 Programa Operacional Temático Factores de Competitividade Funding Fundação para a Ciência e a Tecnologia Grant 5079/2019 Fundação para a Ciência e a Tecnologia Grant IF/00959/2015 Fundação para a Ciência e a Tecnologia Grant ROTEIRO/0031/2013-PINFRA/22161/2016 Fundação para a Ciência e a Tecnologia Grant SFRH/BD/122953/2016 Fundação para a Ciência e a Tecnologia Grant UIDB/00709/2020 Fundação para a Ciência e a Tecnologia Grant UTAP-EXPL/NTec/0015/2017