Viral integration and fusion transcript characteristics of possibly high-risk HPV in cervical cancer

Hong Liu & Hui Wang et al. · 2025-04-01

HPV34, HPV66, HPV73, and HPV82 are classified by the International Agency for Research on Cancer as possibly high-risk HPV (pHR-HPV) types. Despite their relatively lower pathogenicity, some cervical cancer (CC) patients have been found to be infected with pHR-HPV, though the underlying pathogenic characteristics remain unclear. Using viral integration detection and RNA sequencing in 8 pHR-HPV
Links
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Journal
Infection, Genetics and Evolution
TL;DR

Using viral integration detection and RNA sequencing in 8 pHR-HPV+ CC samples, it is identified that the integration of pHR-HPV into the human genome and the formation of pHR-HPV-human fusion transcripts are critical events in cervical carcinogenesis.

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Authors
Hong Liu, Ruiyi Xu, Jinglan Chen, Shuyan Wang, Lingfang Wang, Min Wu, Hui Wang
Funding
China Postdoctoral Science Foundation Grant 2024M762860National Natural Science Foundation of China Grant 82373260National Natural Science Foundation of China Grant 32300460Key Research and Development Program of Zhejiang Province Grant 2022C03013Rajavithi Hospital FundingNatural Science Foundation of Zhejiang Province Grant LQ23H160031