A biochemical study of estrogen receptor beta and oxidative stress in females with ovarian cancer
The study includes the interpretation of hormonal disturbances resulting from the activation of Beta estrogen receptors, which leads to increased oxidative stress and its relationship to the development1and spread of ovarian1cancer in perimenopause women compared to healthy women. Blood samples were collected from (12) perimenopause women with ovarian cancer immediately after diagnosis to be compared with (45) healthy women. Estrogen receptor beta and some hormones were assessed using ELISA and miniVIDAS, while spectrophotometric methods were used to evaluate variables associated with oxidative stress. The results show a significant increase in the values of estrogen receptors beta for women with ovarian cancer (48.4±3.18) ng/mL compared to healthy women (36.20±2.44) ng/mL. Also, a significant increase was remark in the values of each estrogen, progesterone, DHEA-s, testosterone, AMH, and total oxidant status. In contrast, a significant1decrease in the concentrations of total antioxidant capacity. The results also show a positive1correlation between1the values of total oxidants and the hormones studied, compared to the negative correlation with total antioxidants. The significant increase in the values of beta-estrogen receptors as well as the estrogen hormone that may be derived from adipose tissue in women with ovarian cancer in the perimenopause stage has multiple effects, for example, causing disturbances in some hormones such as progesterone, DHEA-s, testosterone, and AMH. These hormonal disturbances resulting from granulosa cell tumors (GCTs) play a role in increasing the metabolic rate and thus increasing the oxidative stress of the cells.