Multifunctional DNA nano-sponge system for targeted sensitization of ovarian cancer chemotherapy via metabolic reprogramming and ferroptosis induction

Dong Kejun & Xiao Xianjin et al. · 2025-03-28

12Citations
The inefficacy of chemotherapy in ovarian cancer, hindered by poor targeting and multiple drug resistance, is intricately linked to the tumor micro-environment and abnormal metabolic patterns. Here, we present ZnO
Links
DOIPubMed
Journal
Journal of Controlled Release
TL;DR

In vitro and in vivo studies demonstrate that ZnOov@DS-DOX effectively modulates tumor metabolic pathways, mitigates drug resistance, and enhances treatment outcomes, representing a significant advancement in nanomedicine and cancer therapy.

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Authors
Dong Kejun, Hu Hao, Cheng Shuangshuang, Mu Yaoqin, Zhang Wei, Zhou Ting, Zhang Jiarui, Shu Wan, Shen Xiaoyu, Wang Hongbo, Xiao Xianjin
Funding
State Key Laboratory of Coal Combustion FundingWuhan Science and Technology Bureau Grant 2022020801010457National Key Research and Development Program of China Grant 2023YFC2705400