Gallium-enriched bimetallic nanomedicine for cervical tumour suppression via bioimaging-guided surgery and highly synergistic reactive oxygen species burst
Cervical cancer continues to pose a substantial global health threat and is the fourth most prevalent cancer among women. Persistent infection with high-risk human papillomavirus is the main cause of the development and progression of these tumours. Unfortunately, the effectiveness of clinical treatments is frequently limited. In this research, we developed a novel one-step method to engineer mesoporous gallium-enriched cerium oxide nanoparticles (Ga&Ce). Indocyanine green (ICG) dye was then encapsulated in the mesopores, creating the Ga&Ce-ICG nanomedicine. This nanomedicine has the remarkable ability to precisely accumulate in tumours and respond to the acidic tumour microenvironment. As a result, ICG, Ce