Ultrasound and glutathione dual-responsive biomimetic nanoplatform for ultrasound/magnetic resonance imaging and sonodynamic therapy of ovarian cancer
Sonodynamic therapy (SDT) has emerged as a promising treatment method for unresectable ovarian cancer (OC) due to its deeper permeability and absence of phototoxicity. However, the low targeting efficiency of sonosensitizers and the hypoxic tumor environment limit the efficacy of SDT, posing significant challenges to tumor treatment. Herein, an ultrasound (US) and glutathione (GSH) dual-responsive SDT nanoplatform, AIPH-MSTN@BSA-MnO