FDX2, an iron-sulfur cluster assembly factor, is essential to prevent cellular senescence, apoptosis or ferroptosis of ovarian cancer cells

Shuko Miyahara & Nobuhiro Tanuma et al. · 2024-08-14

Recent studies reveal that biosynthesis of iron-sulfur clusters (Fe-Ss) is essential for cell proliferation, including that of cancer cells. Nonetheless, it remains unclear how Fe-S biosynthesis functions in cell proliferation/survival. Here, we report that proper Fe-S biosynthesis is essential to prevent cellular senescence, apoptosis, or ferroptosis, depending on cell context. To assess these outcomes in cancer, we developed an ovarian cancer line with conditional KO of FDX2, a component of the core Fe-S assembly complex. FDX2 loss induced global downregulation of Fe-S-containing proteins and Fe
Links
DOIPubMed
Journal
Journal of Biological Chemistry
Institutions
Unknown InstitutionKeio UniversityTohoku UniversityMiyagi Prefectural Hospital Organization
Authors
Shuko Miyahara, Tomoyoshi Soga, Rintaro Saito, Muneaki Shimada, Nobuhiro Tanuma
Funding
Biomedical Data Commons Workbench (BDCW)Data Services CoreData Services CoreBiomedical Data Commons Workbench (BDCW)Princess Takamatsu Cancer Research Fund FundingJapan Society for the Promotion of Science Grant 21K09482Japan Society for the Promotion of Science Grant 23K08577Japan Society for the Promotion of Science Grant 23H02757Japan Society for the Promotion of Science Grant 21K19420

NIH HHS

OT2 OD030544

NIDDK NIH HHS

U2C DK119886

National Institutes of Health

U2C-DK119886

National Institutes of Health

OT2-OD030544