From innate immunity to precision cancer therapy: the clinical advancement of NK cell therapy

Ying Wang & Yizhe Song et al. · 2026-02-17

TL;DR

The findings indicate that NK cell efficacy heterogeneity arises primarily from multiple factors: immunosuppression within the tumor microenvironment (TME), inadequate tumor infiltration capacity, heterogeneity in target antigen expression, and inhibitory receptor signaling.

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Authors
Ying Wang, Yu Yu, Siyu Wang, Jiangyong Qu, Yizhe Song