UBC6 mediated the inhibitory effect of quercetin on ovarian cancer through the PRKN-AURKA-AMPK axis
Ovarian cancer (OC) is the most lethal gynecological malignancy with high recurrence rate and short survival. As a kind of phytochemical, quercetin has been demonstrated as a broad spectrum of antitumor activities. Ubiquitin-conjugating enzyme E2 J1 (UBC6) was screened as a candidate target of quercetin by Label-free proteomic analysis. However, the function and mechanisms of UBC6 in OC development remain largely unknown. In this study, lentiviruses targeting UBC6 were constructed to infect Caov-3 and SKOV-3 cells and an OC mouse model was constructed by injecting 5 × 10