The interaction between IL-33 and TRIM28 in the regulation of macrophage polarization in an ST2-independent manner
The tumor microenvironment provides optimal condition for the growth of ovarian cancer. Macrophages display a highly functional plasticity to respond various signals. Switching macrophages' phenotype is a potential therapeutic strategy for the treatment of cancer. We used RNA-sequencing(RNA-Seq) and Chromatin immunoprecipitation-sequencing(ChIP-Seq) analyses in bone-marrow-derived macrophages (BMDMs) from wild-type (WT) and its receptor interleukin-1 receptor like-1 (IL1RL1 or ST2) knockout(ST2